Eddie is a Research Associate in the lab. He received his B.S. in biochemistry from Manhattan College and his Ph.D. from Yale University in 2017. His doctoral work focused on genome engineering technologies. Eddie enjoys hockey, skateboarding, ‘90s hip-hop, and spicy food. At Yale he won a National Science Foundation Graduate Research Fellowship and the Spangler Prize for outstanding Ph.D. thesis. In 2018, Eddie won a Milton Safenowitz Post-Doctoral Fellowship from the ALS Association. In 2019, Eddie was awarded a Ruth L. Kirschstein National Research Service Award (NRSA) from the National Institute of Neurological Disorders and Stroke (NINDS). In 2023, Eddie was awarded an NIH Pathway to Independence Award (K99/R00) from the National Institute on Aging (NIA).
Publications
Sweeney, K.M., S. Chantarawong, E.M. Barbieri, G. Cajka, M. Liu, L. Spruce, H. Fazelinia, B. Portz, K. Copley, T. Lapidot, L. Duhamel, P. Greenwald, N. Saida, R. Shalgi, J. Shorter, and O. Shalem. (2024). CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. PLoS Genet. 20(2):e1011138. pdf file link
Mack, K.L.*, H. Kim*, E.M. Barbieri, J. Lin, S. Braganza, M.E. Jackrel, J.E. DeNizio, X. Yan, E. Chuang, A. Tariq, R.R. Cupo, L.M. Castellano, K.A. Caldwell, G.A. Caldwell, and J. Shorter. (2023). Tuning Hsp104 specificity to selectively detoxify α-synuclein. Mol. Cell. 83(18):3314-3332.e9. pdf file link (*Co-first author.).
François-Moutal, L., D.D. Scott, A.J. Ambrose, C.J. Zerio, M. Rodriguez-Sanchez, K. Dissanayake, D.G. May, J.M. Carlson, E. Barbieri, A. Moutal, K.J. Roux, J. Shorter, R. Khanna, S.J. Barmada, L. McGurk, and M. Khanna. (2022). Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with neurodegenerative disease pathology. Sci. Rep. 12:8140. pdf file link
Peinado, J.R., K. Chaplot, T.S. Jarvela, E. Barbieri, J. Shorter, and I. Lindberg. (2022). Sequestration of TDP-43(216-414) aggregates by cytoplasmic expression of the proSAAS chaperone. ACS Chem. Neurosci. 13(11):1651-1665. pdf file link
Aikio, M., H.J. Wobst, H.M. Odeh, B.L. Lee, B. Class, T.A. Ollerhead, K.L. Mack, A.F. Ford, E.M. Barbieri, R.R. Cupo, L.E. Drake, N. Castello, A. Baral, J. Dunlop, A.D. Gitler, A. Javaherian, S. Finkbeiner, D.G. Brown, S.J. Moss, N.J. Brandon, and J. Shorter. (2021). Opposing roles of p38α-mediated phosphorylation and arginine methylation in driving TDP-43 proteinopathy. BioRxiv. doi:10.1101/2021.08.04.455154. pdf file link
Barbieri, E.M., and J. Shorter. (2019). TDP-43 shapeshifts to encipher FTD severity. Nat. Neurosci. 22(1):3-5. pdf file link
Barbieri, E.M., P. Muir, B.O. Akhuetie-Oni, C.M. Yellman, and F.J. Isaacs. (2017). Precise Editing at DNA Replication Forks Enables Multiplex Genome Engineering in Eukaryotes. Cell. 171(6):1453–1467. pdf file link
Levee, L., C. Calogeroa, E. Barbieri, S. Byrne, C. Donahue, M. Eisenberg, S. Hattenbach, J. Le, J.F. Capitani, J. Roithová, and D. Schröder. (2012). Formation of argon–boron bonds in the reactions of BFn+/2+ cations with neutral argon. Int. J. Mass Spectrom. 323-324:2-7. pdf file link
